It remained normal throughout the experimental period. The control group was not affected either clinically, pathologically or biochemically. Substitution of diet has led to the reduction of cpc level on day-2 and appeared to reach the same level as in control group on day-21. On the other hand, creatinine phosphokinase (CPK) was affected in which higher level was noted in treated groups than control. However, these enzymes increased on day-3 after substitution and appeared to maximum followed by a reduction of enzymatic activities in week-4. ![]() The substitution of diet showed an increased of enzymatic activities during the first two weeks of feeding then reduced at the subsequent weeks. Both enzymes in treated animals were lower than the control. As far as alcohol is concerned, one distinguishes between ' normal ' and pathological alcohol intoxication. The Legal Defense of Pathological Intoxication by Tiffany Lawrence P. substance intoxication a type of substance-induced disorder, consisting of reversible, substance-specific, maladaptive behavioral or psychological changes directly resulting from the physiologic effects on the central nervous system of recent ingestion of or exposure to a drug of abuse. Enzymatic activities of alanine aminotransferase (ALAI) and aspartate aminotransferase (ASAT) were not affected. pathological intoxication alcohol idiosyncratic i. But, myocardial appeared to be regenerated two days after the substitution of diet. Regeneration of skeletal muscle developed on day-5 after the substitution of mindi diet by normal diet indicated by disappearing of hyalin tissues. Following the skeletal muscle lesions, myocardial showed degeneration, necrosis and fragmentation of fibres enlargement of nuclei and hypercellularity. The hyalination was prominent and appeared to be more. There were degeneration, necrosis and fragmentation of muscle fibres enlargement of nuclei fibrosis oedema and hyalination. Intoxication is pathological if it is a result of. ![]() Skeletal muscle lesions on the other hand, were consistently noted microscopically. PATHOLOGICAL INTOXICATION Involuntary intoxication also includes instances of pathological intoxication. Specific pathological changes were not found macroscopically except cachexia and paleness. Clinical signs did not appear the intoxication of mindi leaf. Fifty two male Wistar rats weighing 140 g to 240 g were intoxicated in 20% 25% and 40% diet of mindi leaf ad libitwn for 25 days. The purpose of this study was to investigate pathological and biochemical changes in intoxication of mindi leaf (Melia azedarach) on skeletal muscle and myocardial tissues.
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